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Telfairia occidentalis Hook. F. is an edible vegetable, rich in essential diet components and contains protein, vitamins, iron, calcium and other nutrients, which are not adequately supplied in our diet. However, Telfairia occidentalis is believed to contain heavy metals over a range of concentrations which could pose potential health risk to the consumers. The objective of this study was to determine whether the concentration of selected heavy metals present in Telfairia occidentalis cultivated in twenty Local Government areas of Lagos State, Nigeria, are within the acceptable range for human consumption.