alexa Evaluation of Anti Inflammatory Activity of Hydroalcoholic Leaves Extracts of Polyherbal Combination of Vitex Negundo and Murraya Koenigii against Carrageenan Induced Paw Edema in Rats

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Evaluation of Anti Inflammatory Activity of Hydroalcoholic Leaves Extracts of Polyherbal Combination of Vitex Negundo and Murraya Koenigii against Carrageenan Induced Paw Edema in Rats

After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha and Unnani. This is because of the adverse effects associated with synthetic drugs. Herbal drugs play an important role in health care programs especially in developing countries. Ancient Indian literature incorporates a remarkably broad definition of medicinal plants and considers ‘all plant parts to be potential sources of medicinal substances’ [1].

Murraya koenigii is known as ‘curry patta’ in Hindi and widely used as spice and condiment in India and other tropical countries. It belongs to the family Rutaceae [2]. Traditionally, the plant is used as a stimulant, stomachic, febrifuge, analgesic and for the treatment of diarrhoea, dysentery; insect bites and also used to allay heat of body [3]. Previous Phytochemical investigations on this plant revealed Analgesic, Wound Healing, Antidiarrhoeal, Anthelmintic, Antibacterial, Antifungal, Antiulcer, Antiobesity, and Hypoglycaemic activities. Vitex Negundo Linn. commonly known as Negundo, has been used by several traditionalsystems of medicine including Ayurveda, Unani and Siddha for different ailments. It belongs to the family Verbanaceae [4]

. Vitex Negundo is commonly known as five leaved chaste tree (English), Nirgudi (Marathi), Nirgundi (Hindi), Indrani (Sanskrit) [5]. This plant has reported the Antipyretic, Antidiabetic, Laxative, Anticonvulsant, Antitumor, Wound Healing and Anthelmintic activities. It is also useful in leucoderma and blood disorders. An infusion of the toasted leaves in used to stop vomiting [6]. Crushed leaves are applied externally cures skin eruption and to relieves burn. The pastes of leaves are applied externally to treat the bites of poisonous animals [7]. Steam distillate of the leaves can be used as stomachic, purgative, febrifuge and antiemetic [8]. Leaves are applied externally to bruises and eruption [9].

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