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In this paper is tried to put forward the important differences in preparation condition of platelets(PLTs) concentrates (PCs) as pharmaceutics- therapeutically products. Although it looks like a very simple task but the ‘knowledge’ behind human PLTs and derivatives transfusion is more than only isolation, preparation and storage of a blood product. Moreover, the PLTs are very fragile blood cells, and the related Transfusion Medicine procedures are complex basic Medical Sciences. Worldwide, there is ‘limited published standard’ procedure for appropriate PCs and derivatives preparation (product quality issues). After all, prepared PCs should be transfused to a random (unknown) matched recipients with bleeding disorders, and PLTs function defect (unknown recipient issues).
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