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Probiotic is a live microbial supplement which affects host’s health positively by improving its intestinal microbial balance. The probiotic concept is open to lots of different applications in a large variety of fields relevant for human and animal health. Probiotic products consist of different enzymes, vitamins, capsules or tablets and some fermented foods contain microorganisms which have beneficial effects on the health of host. The probiotic preparations use for traveller’s diarrhea, antibiotic associated diarrhoea and acute diarrhoea which is showed that they have positive therapeutic effect.