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Vitamin k Antagosnist Oral Anticoagulants (VKA) is effective in the primary and secondary prevention of venous thromboembolism, in the prevention of systemic embolism and stroke in patients with prosthetic heart valves or atrial fibrillation. In patients with thromboembolic disease Low Molecular Weight Heparin (LMWH) and oral VKA are started at diagnosis. LMWH is than stopped once the International Normalised Ratio (INR) values are in the therapeutic range.
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