alexa Different Strategies for Post-SELEX Optimization of Aptamers

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Different Strategies for Post-SELEX Optimization of Aptamers

Aptamers are oligonucleotides selected in vitro by SELEX (Systematic Evolution of Ligands by Exponential Enrichment) which can form a special three-dimensional structure and bind its target with high affinity and specificity. With many advantages over antibodies, such as stability and non-immunogenicity, aptamers show good prospects. However, just a few aptamers have entered clinical trials and only one, pegaptanib, has been approved by FDA for clinical use, because of their insufficient nuclease stability, thermal stability, bioavailability or even affinity.

Citation: Zheng X, Hu B, Gao SX, Sun MJ, Wang LH (2015) Multiple Different Strategies for Post-SELEX Optimization of Aptamers. J Mol Biomark Diagn 6:224.

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