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Aptamers are oligonucleotides selected in vitro by SELEX (Systematic Evolution of Ligands by Exponential Enrichment) which can form a special three-dimensional structure and bind its target with high affinity and specificity. With many advantages over antibodies, such as stability and non-immunogenicity, aptamers show good prospects. However, just a few aptamers have entered clinical trials and only one, pegaptanib, has been approved by FDA for clinical use, because of their insufficient nuclease stability, thermal stability, bioavailability or even affinity.