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In critical care settings, patients with acute kidney injury (AKI) constitute an important subgroup, in that they have higher shortand long-term mortality, prolonged hospital length of stay, and more resource consumption. Incidence of AKI in intensive care unit (ICU) patients ranges between 20-70% according to settings, and, among these, patients who undergo renal replacement therapy (RRT) portend even worse outcome. RRT-treated AKI patients have on average 50-70% in-hospital mortality (depending on AKI etiologies), and 25-50% patients develop chronic kidney disease (CKD) thereafter without complete recovery of renal function. Consequently, better understanding of the precipitating factors of AKI in these critically ill patients is of paramount importance for clinicians to reduce the incidence of AKI in ICUs.
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