alexa Effect of Mastitis on Pharmacokinetics of Levofloxacin Following Single Dose Intravenous Administration in Goats

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Effect of Mastitis on Pharmacokinetics of Levofloxacin Following Single Dose Intravenous Administration in Goats

Levofloxacin (LVX), a third-generation fluoroquinolone and L-isomer of ofloxacin possess a broad-spectrum antimicrobial activity and active against most gram-positive, gram-negative and anaerobic bacteria. It is also active against several species of Staphylococci, Streptococci including Stretococcus pneumonia, Bacteroides, Clostridium, Haemophilus, Moraxella, Legionella, Mycoplasma and Clamydia. It acts by selective inhibition of bacterial enzymes DNA gyrase and Topoisomerase IV. LVX is widely distributed throughout the body and penetrates well into most body fluids and its uptake by phagocytic cells makes it suitable for use against intracellular pathogens. Levofloxacin concentrations in tissues and fluids are generally greater than those observed in plasma, but penetration into the cerebrospinal fluid is relatively poor. LVX is excreted through urine as unchanged drug and less than 5% is metabolized in the liver to demethyl-levofloxacin and levofloxacin-N-oxide and excreted in the urine of rats and humans. Fluoroquinolones act by a concentrationdependent killing mechanism, whereby the optimal effect is attained by the administration of high doses over a short period of time.

Citation: Ram M, Singh V, Roy BK, Prasad R, Singh KK (2011) Nicotinamide Phosphoribosyltransferase in Rheumatoid Arthritis. J Bioanal Biomed 3:081-084.

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