alexa Effect of antiepileptic drugs on antioxidant status in epilepsy

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Effect of antiepileptic drugs on antioxidant status in epilepsy

The present study comprised of 60 patients of epilepsy grouped as 30 patients with regular antiepileptic drugs (phenytoin and carbamazepine) treatment and 30 patients with irregular treatment with antiepileptic drugs (phenytoin and carbamazepine) and compared with normal 30 controls. Lipid peroxidation in patients with regular and irregular treatment was significantly high compared with controls. Erythrocyte superoxide dismutase (SOD) and plasma vitamin E levels were significantly lower in both the groups of patients, while the levels were also found significantly lower in irregular treatment patients as compared with regular treatment patients. This study suggests that though epilepsy is lowering antioxidant status of patients, regular treatment with antiepileptic drugs is beneficial to restore antioxidant levels near normal.

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