alexa COP9 Signalosome in Gastrointestinal Cancers

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COP9 Signalosome in Gastrointestinal Cancers

The COP9 signalosome (CSN) is an evolutionarily conserved multi-protein complex found in plants and animals. In mammals, the CSN consists of eight subunits (CSN1-CSN8). It has been suggested to play a key role in tumorigenesis, because its subunits are frequently overexpressed in human cancers and because the CSN is involved in the regulation of a number of processes that are relevant to carcinogenesis and cancer progression, CSN regulates the degradation of several tumor suppressors and oncogenes that are degraded by the 26S proteasome.

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