alexa Regulation of Mirna Pathway and Roles of Micrornas in Tumorigenesis and Metastasis

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Regulation of Mirna Pathway and Roles of Micrornas in Tumorigenesis and Metastasis

Small non-coding RNAs, identified so far including small interference RNA (siRNAs), microRNAs (miRNAs), piwi-interacting RNA (piRNAs), promoter-associate (paRNAs), transcription initiation tiRNA, and tRNA-derived RNA fragments (tRFs), are 18-30 nucleotides in length. Although they account for only a very small fraction of the expressed genome, these small RNAs, have been acknowledged as pivotal regulators at post-transcriptional levels to control diverse biological pathways relating to chromosome architecture and segregation behavior, transcription, and RNA processing and stability, and thereby to phenotypically coordinate development, growth control, apoptosis, self-defense, and stem cell maintenance.

 

Citation: Jiang R, Li Y (2013) Regulation of Mirna Pathway and Roles of Micrornas in Tumorigenesis and Metastasis. Human Genet Embryol S2:007

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