alexa Aberrant DNA Methylation of Ribosomal RNA Genes in Human Cancer

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Aberrant DNA Methylation of Ribosomal RNA Genes in Human Cancer

In mammalians, three classes of RNA polymerases (Pol I, II and III) transcribe distinct sets of genes. About 70% of Pol II promoters are localized at GC- and CpG-rich sequences termed CpG islands. Active CpG island promoters are in an open chromatin configuration, which is devoid of cytosine methylation. DNA hypermethylation of CpG island promoters is associated with gene silencing and this epigenetic inactivation contributes to the pathogenesis of cancer. Aberrant methylation of rDNA has been reported in cancer, but also in neuropsychiatric disorders. Pol I transcribes the ribosomal RNA (rRNA) genes that are organized in multiple tandem repeats of about 400 copies in satellite regions of acrocentric chromosomes of the diploid human genome.

Citation: Teschler S, Richter AM, Linder B, Dammann RH (2015) Aberrant DNA Methylation of Ribosomal RNA Genes in Human Cancer. Mol Biol 4:128.

 
  • Share this page
  • Facebook
  • Twitter
  • LinkedIn
  • Google+
  • Pinterest
  • Blogger
 
adwords