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The Middle East Respiratory Syndrome coronavirus (MERS-CoV) was first detected in June 2012 in Saudi Arabia. Since then the virus is predominantly detected in the Arabian Peninsula. Other countries were also involved, but the majority of their affected cases were linked to travel to the Arabian Peninsula or caused by a contact with travelers. In Kuwait, one of the Arabian Peninsula countries, despite active surveillance and vigilance, only three cases have been discovered so far. In this report we describe our experience and findings highlighting the virological response to the different treatment regimens adopted in managing both patients.