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In December 2012, the Food and Drug Administration approves apixaban for reducing risks of stroke and venous thromboembolism in patients with nonvalvular atrial fibrillation (NAF) [1]. Apixaban is the third new oral anticoagulation agent that came into the market [1-3]. Prior to the approval of apixaban, dabigatran (a direct thrombin inhibitor) was approved in 2010, and rivaroxaban (a factor Xa inhibitor) was approved in November 2011. All of these agents have been compared to warfarin in various landmark trials
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