alexa Enhanced Solubility and Dissolution Rate of Aceclofenac by Using Spray Drying Techniques

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Enhanced Solubility and Dissolution Rate of Aceclofenac by Using Spray Drying Techniques

Today, 35-40% all new chemical entities suffer from poor aqueous solubility. The poor solubility and low dissolution rate of poorly water soluble drugs in the aqueous gastro-intestinal fluids often cause insufficient bioavailability. And therefore Improvement of the solubility of poorly water-soluble drugs is one of the most challenging aspects in formulation development. The model drug mentioned is practically water insoluble. It belongs to BCS class II and its bioavailability dissolution dependent. Due to poor aqueous solubility of the model drug it is chosen as a drug candidate to improve its solubility and bioavailability. Various techniques are followed to improve solubility of drug. Preparation of Solid Dispersion of drug is one of the techniques to enhance solubility.

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