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Looking at the population aged 65 and higher, every second person suffers from the disease, with increasing degeneration of cartilage and ultimately destruction of the underlying bone as well. The etiologyof osteoarthritis (OA) is still unknown. Therapy is currently mainly symptomatic with reduction of pain and inflammation, but not restorative, and is often ending in total joint replacement. The research project GAMBA (Gene Activated Matrices for Bone and Cartilage Regeneration in Arthritis) (www.gamba-project.eu)was investigating new methods to induce regenerative processes within the body.