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Drug targeting represents a challenging approach with promising potential to circumvent some problems associated with many toxic effects of antineoplastics drugs. The objective of the present study was to develop PLGA nanoparticles surface modified with cetuximab to deliver in a targeted fashion sorafenib into undifferentiated/anaplastic thyroid carcinoma cell line as an efficient in vitro model Sorafenib loaded nanoparticles were obtained by the single emulsion evaporation method and characterized in terms of size (252 nm), charge (-14.6 mV), morphology (spherical), drug entrapment efficiency (58%) and in vitro drug release.View more....
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