Different methods have been adopted to create an enhanced vaccine for humans. The objective is to develop a vaccine that is non reactogenic and involves little administration to perform efficiently. However, the difficult aspect of checking the potency of anthrax vaccine is making an assessment in humans. Tests using this pathogenic bacteria is not safe for humans and animals and requires special precautions.
Anthrax is as old as man, it was given its name by a Greek physician named Hippocrates because of the black sore it causes on the skin of human and animals.
Bacillus anthracis contains two toxic plasmids: the pX01, which produces the edema factor, the protective antigen and lethal factor, and the pX02.Bacillus anthracis carries out its pathogenic process by using its capsule and producing toxics consisting of three proteins (EF, LF and PA).