The antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by a combination of arterial and/or venous thrombosis, recurrent fetal loss, often accompanied by a mild-to-moderate thrombocytopenia, and elevated titers of antiphospholipid antibodies (aPL), namely, the lupus anticoagulant (LA) and/or anticardiolipin antibodies (aCL). Antiphospholipid syndrome occurs when r immune system mistakenly attacks some of the normal proteins in blood.
In antiphospholipid syndrome, body mistakenly produces antibodies against proteins that bind phospholipids, a type of fat present in blood that plays a key role in clotting (coagulation). Antibodies are specialized proteins that normally attack body invaders, such as viruses and bacteria. When antibodies attack phospholipid-binding proteins, blood may clot abnormally.
Doctors generally use medications that reduce r blood's tendency to clot to treat antiphospholipid syndrome. This doesn't cure the disease but does help to prevent its most serious complications.