Diabetes insipidus is an uncommon disorder characterized by intense thirst, despite the drinking of fluids (polydipsia), and the excretion of large amounts of urine (polyuria).Diabetes insipidus is caused by abnormality in the functioning or levels of antidiuretic hormone (ADH), also known of as vasopressin.It is manufactured in the hypothalamus and stored in the pituitary gland, ADH helps to regulate the amount of fluid in the body. ADH is released from the pituitary gland which prevents the excretion of fluids from the body in the form of urine. There are four types of diabetes insipidus Central diabetis insipidus or Cranial Diabetis insipidus and Nephrogenic diabetes insipidus.
Treatment mainly aim to reduce to reduce the amount of urine your body produces. Mild cranial diabetes insipidus may not require any medical treatment, the only think to do is to increase the amount of water consumption. Central diabetes insipidus may be controlled with desmopressin,it is a synthetic analogue of antidiuretic hormone (ADH). Desmopressin is available either an injection, a nasal spray, or tablets Generally, it can be administered 2-3 times per day. Patients may require hospitalization to establish fluid needs. Frequent electrolyte monitoring is recommended during the initial phase of treatment. Nephrogenic DI is treated with anti-inflammatory medicines and diuretics.
The extrapolated incidence in Brazii is 27,615. The population estimated used is 184,101,109. The statistical data of Diabetis Insipidus is From 2006 to 2010, an approximate 20% increase in the prevalence of self-reported diabetes was observed. In 2010, it was estimated that 6.3% of Brazilians aged 18 years or over had diabetes. Diabetes was estimated to be responsible for 278,778 years of potential life lost for every 100,000 people. In 2013, it is estimated that about 7% of patients with diabetes has had one or more of the following complications: diabetic foot ulcers, amputation, kidney disease, and fundus changes.
1)Epidemiology, management, complications and costs associated with type 2 diabetes in Brazil: a comprehensive literature review. 2)Ion channelopathies in endocrinology: recent genetic findings and pathophysiological insights.3) Identification of novel mutations of the WFS1 gene in Brazilian patients with Wolfram syndrome