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Membranous Nephropathy

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  • Membranous nephropathy


    Membranous nephropathy is quite rare among the general population but is one of the more common glomerular diseases. Membranous nephropathy is characterized by diffuse thickening of the glomerular capillary basement membrane by subepithelial immune complex deposition.

  • Membranous nephropathy

    Disease pathophysiology: 

    Membranous nephropathy occurs when the small blood vessels in the kidney (glomeruli), which filter wastes from the blood, become inflamed and thickened. As a result, proteins leak from the damaged blood vessels into the urine (proteinuria). For many, loss of these proteins eventually causes signs and symptoms known as nephrotic syndrome.

     

  • Membranous nephropathy

    Disease statistics: 

    Membranous nephropathy is the most important cause of the nephrotic syndrome in elderly patients (aged >65 years). The clinical presentation is similar in older and younger patients, although elderly patients more often present with renal failure. Notably,glomerular filtration rate (GFR) is usually lower in the elderly due to the physiological decline in GFR after the age of 30 years.

     

  • Membranous nephropathy

    Disease treatment: 

    The goal of treatment is to reduce symptoms and slow the progression of the disease. The goal is to keep blood pressure at or below 130/80 mmHg. Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) are the medicines most often used to lower blood pressure. Corticosteroids and other drugs that suppress the immune system may be used. High blood cholesterol and triglyceride levels should be treated to reduce the risk of atherosclerosis.

  • Membranous nephropathy

    Major research on disease:

    Discriminating between cases of primary and secondary Membranous Nephropathy (MN). However, a low-fat, low-cholesterol diet is usually not as helpful for people with membranous nephropathy. Medications to reduce cholesterol and triglyceride levels (most often statins) may be recommended.

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    Effects of Pravastatin or 12/15 lipoxygenase pathway inhibitors on indices of Diabetic nephropathy in an experimental model of diabetic renal disease
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