Membranous nephropathy occurs when the small blood vessels in the (glomeruli), which filter wastes from the blood, become inflamed and thickened. As a result, proteins leak from the damaged blood vessels into the urine (). For many, loss of these proteins eventually causes signs and symptoms known as
Membranous nephropathy is the most important cause of the nephrotic syndrome in elderly patients (aged >65 years). The clinical presentation is similar in older and younger patients, although elderly patients more often present with renal failure. Notably,rate (GFR) is usually lower in the elderly due to the physiological decline in GFR after the age of 30 years.
The goal of treatment is to reduce symptoms and slow the progression of the disease. The goal is to keep blood pressure at or below 130/80 mmHg. Angiotensin-converting enzyme (ACE) inhibitors and receptor blockers (ARBs) are the medicines most often used to lower blood pressure. Corticosteroids and other drugs that suppress the immune system may be used. and triglyceride levels should be treated to reduce the risk of atherosclerosis.
Major research on disease:
Discriminating between cases of primary and secondary Membranous Nephropathy (MN). However, a low-fat, low-cholesterol diet is usually not as helpful for people with membranous nephropathy. Medications to reduce cholesterol and triglyceride levels (most often statins) may be recommended.