Identification of variables that determine the prognosis for osteosarcoma may enable stratification of patients into subgroups with better or worse risk of local recurrence, metastases and death due to the disease. To identify prognostic factors related to local recurrence-free survival, metastasis-free survival and overall survival among patients with highly malignant primary osteosarcoma that was non-metastatic on diagnosis and had poor response to neoadjuvant chemotherapy.
Out of 45 patients admitted to a referral centre in Brazil between 2000 and 2004, 24 were selected for this study. Among the 24 patients studied, 14 (58.3%) were male and 10 (41.7%) were female, with a proportion of 1.4:1.0. Their ages ranged from 5 to 44 years, with a mean of 15.75 ± 7.57 years (median of 15 years). Pulmonary metastasis was identified in nine patients (37%).
The histological type of osteosarcoma is a significant independent predictor for LRFS, MFS and OS. Although initially diagnosed by a primary care physician, Endocrinologists, rheumatologists, orthopedic specialists, neurosurgeons, neurologists, oral and maxillofacial specialists, podiatrists, and otolaryngologists are by and large learned about treating Paget's malady, and may be called upon to assess particular indications. The goal of treatment is to relieve bone pain and prevent the progression of the disease.