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Wegeners Granulomatosis

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  • Wegeners granulomatosis

    Pathophysiology: Wegener’s Granulomatosis (WG) is a necrotizing vasculitis that affects small and medium-size blood vessels with granulomata formation. It is one of the most common forms of systemic vasculitis, with a reported annual incidence of 10 cases per one million people. Its causes are unknown, and it is the prototype of conditions associated with anti-neutrophilic cytoplasmic antibody (ANCA).2 It affects mainly Caucasian individuals, without gender predilection, with a mean age of onset of 41 years.

     

  • Wegeners granulomatosis

    Diagnosis: Whenever possible, it is important to confirm the diagnosis of Wegener’s by biopsying an involved organ and finding the pathologic features of this disease under the microscope. Because many diseases may mimic Wegener’s (and vice versa), before starting a treatment regimen it is essential to be as certain of the diagnosis as possible.

  • Wegeners granulomatosis

    Treatment 
    Corticosteroids: Medications such as prednisone help suppress the immune system and treat the early signs and symptoms of Wegener's granulomatosis. 
    Immune suppressant medications: Most people require another immunosuppressive drug, such as cyclophosphamide, azathioprine or methotrexate, to counteract the body's immune reaction.

  • Wegeners granulomatosis

    Research: Faculdade de Medicina da Universidade de São Paulo, Division of Rheumatology conduted a research work on WG. Most epidemiological studies with Wegener's granulomatosis (WG) patients are based on populations from the Northern hemisphere. The authors performed a large retrospective, demographic study including clinical and laboratory profiles of 134 consecutive WG patients seen at one Brazilian center from 1999 to 2009. Here were 29 deaths (21.6%).

 

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