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ISSN: 2155-9864
Journal of Blood Disorders & Transfusion

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Can Plasma Donation Induce Coronary-Artery Thrombosis?

G Leurent1,2,3,4*, M Bedossa1,2,3,4, C Camus5,6, N Behar1,2,3,4 and P Mabo1,2,3,4

1CHU Rennes, Service de cardiologie et maladies vasculaires, Rennes, F-35000, France

2Université de Rennes 1, LTSI, Rennes, F-35000, France

3INSERM, U642, Rennes, F-35000, France

4INSERM, CIC-IT 804, CHU de Rennes, F-35000, France

5CHU Rennes, Service de maladies infectieuses et réanimation médicale, Rennes, F-35000, France

6INSERM, U835, Rennes, F-35000, France

*Corresponding Author:
Dr. Guillaume Leurent
Service de cardiologie et maladies vasculaires
CHU de Rennes, Cedex 35033
Rennes, France
E-mail: [email protected]

Received date: October 12, 2010; Accepted date: November 21, 2010; Published date: November 23, 2010

Citation: Leurent G, Bedossa M, Camus C, Behar N, Mabo P (2010) Can Plasma Donation Induce Coronary-Artery Thrombosis? J Blood Disord Transfus 1:103. doi: 10.4172/2155-9864.1000103

Copyright: © 2010 Leurent G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

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Abstract

Plasmaphereis donation is supposed to be safe. However, we report the case of a 47-year old man without any cardiovascular risk factors or medical history, except being a large volume plasmapheresis donor. Twenty four hours after a plasmapheresis, he presented a sudden death due to an acute myocardial infarction caused by a thrombotic lesion. The only funded etiology of this arterial thrombosis is the recent plasmapheresis donation. Although this technique is known to be safe, this report is the third one published about a life threatening arterial thrombosis due to apheresis donation, raising the interrogation about it harmlessness.

Keywords

Plasmapheresis; Arterial thrombosis; Adverse effects; Acute coronary syndrome

Introduction

Plasmapheresis donation (PD) is reported to be a safe technique. However, our report of life-threatening coronary artery thrombosis raises interrogation about its harmlessness.

Case report: A 47-year old man was referred to our institution for an anterior acute myocardial infarction (MI) complicated by ventricular fibrillation (VF). The patient was a marathon runner without any cardiovascular risk factors, treatment or medical history, except being a large volume plasmapheresis donor (a total of 21 donations, including 5 in 2009). The last donation which occurred the day before MI was standard and apparently uncomplicated (sampling time: 48 minutes). The collected volume was 724 ml; anticoagulant 144 ml; device PCS 2® (Haemonetics, Braintree, US); free interval from the precedent donation: 53 days. The patient received an oral compensation of 50 cl of beverage, and rest for the day, as recommended in our institution.

Twelve hours after PD, the patient presented digestive discomfort followed by a sustained chest pain. Twelve hours later, he experienced sudden death related to VF. After a 45 min resuscitation, as the electrocardiogram showed anterior acute MI, the patient was given aspirin, clopidogrel, unfractionned heparin, and was transferred to our institution for a primary percutaneous coronary intervention (time from PD to balloon: 26 hours, from chest pain to balloon: 14 hours, from sudden death to balloon: 2 hours). The coronary angiography (Figure 1) showed a thrombotic subocclusion of the proximal left anterior descending artery (LAD), with a TIMI grade flow 2. Thromboaspiration was performed but, because of a persistent low flow, an angioplasty was necessary, with implantation of a bare metal stent. Final TIMI grade flow was 3 on the LAD (Figure 2) and no other lesion was noticed on the circumflex and right coronary arteries.

blood-disorders-transfusion-Initial-coronary

Figure 1: Initial coronary angiography showing a thrombotic subocclusion of the proximal left anterior descending artery (LAD).

blood-disorders-transfusion-Coronary-angiography

Figure 2: Coronary angiography after thromboaspiration and implantation of a stent.

After the procedure, the patient presented with cardiogenic shock, rhythmic storm and multiple organ failure, requiring catecholamines and implantation of a circulatory assist device (extra corporeal membrane oxygenation) for 7 days.

After 6 weeks, trans thoracic echo showed a non dilated left ventricle with a large anteroapical akinesia with ejection fraction of 35%. At 4 months, he had only minimal memory loss.

Blood test showed absence of diabetes, hypercholesterolemia, haemostasis abnormality, hyperhomocysteinemia and antiphospholipid syndrome. Metabolic balance at the admission was normal, as platelet count (193.109/l). Researches for vasculitis, heparin-induced thrombocytopenia and for thrombophilia were negative: antithrombin III: 109%, protein C: 121%, protein S: 87%, absence of factor II or V (Leiden) mutation, absence of activated protein C resistance. No supra ventricular arrhythmia was documented during the hospitalisation of the patient.

Discussion

PD is reported to be safe. Mostly reported adverse events are hypotensive or vasovagal episodes, pain or hematoma at venipuncture site. More severe events like thrombophlebitis or citrate toxicity are rare [1-6]. However, significant decrease in haemoglobin concentration, haematocrit, platelet and white blood cell counts after each procedure has been reported [7], with a significant increase in endogenous thrombopoietin, a key cytokine involved in the regulation of platelet production [8]. PD may also elongate prothrombin time [9], and decrease plasminogen levels [10], without any change in the plasma level of prothrombin fragment [11].

Nevertheless, the causal relationship to MI was possible, because of 1. time sequence of events (MI occurring 24 hours after PD); 2. mechanism of coronary occlusion (isolated thrombus without any atherosclerotic disease on the coronary angiogram); 3. absence of other “usual” causes of MI, especially neither cardio vascular risk factors, haemostasis abnormalities, nor evidence for stress.

 

Several mechanisms can possibly explain arterial thrombosis in this circumstance: It has been shown that the platelets-derived growth factor (isoform AB) concentration was multiplied by a factor of 1.8 at the end of an apheresis for about an hour [12]. Apheresis may generate platelet activation with an increase of the surface expression of glycoproteins CD41a, CD42b, CD62p, and CD63, circulating for at least 48 hours following plasmapheresis [13,14]. It also causes a significant increase in platelet-neutrophil complex formation in donors with a decrease in CD62L expression which is a sign of mild neutrophil activation [15]. Furthermore, apheresis increases prothrombin fragment-F1 + 2, thrombin antithrombin III complex and fibrinopeptide A, causing a hypercoagulable state [16]. Finally, combined to the presence of activated platelets with platelet-leukocyte aggregates, hypovolemia may contribute to the hypercoagulable state, which might predispose certain donors to thrombotic complications following apheresis.

Two cases of arterial thrombosis have previously been reported. The first one concerned a 48-year old man who presented cerebral infarction 3 hours after a 1200 ml plasma donation. Etiologic check-up revealed haemostasis anomalies (heterozygous for both methylene tetrahydrofolate reductase 677c-T mutation and prothrombin 20210G-A allele) [17]. The second was an acute anterior MI immediately following platelet apheresis (total volume depletion: 663 ml) in a 57-year old donor, with a negative etiologic check-up. Nevertheless, in this second case, the infarction occurred 10 minutes after the apheresis and was preceded by a vaso-vagal reaction, so the hypothesis of a prolonged spasm cannot be eliminated [18].

Our case is the first one reporting arterial thrombosis which occurred after a 24-hour free interval following PD, without any other promoting factor, despite a regular hydratation. This raises interrogation about the harmlessness of apheresis donation.

References

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