Aldosteronoma are tumours that arise from a specific area in the adrenal cortex. These tumours tend to be benign with only about 5 percent being malignant. Adrenal glands are located just above each kidney and are part of the endocrine system. One function of the adrenal glands is to produce the hormone aldosterone, which regulates blood pressure and potassium levels in the blood. Aldosteronoma tend to produce excess aldosterone, which causes high blood pressure and low potassium blood levels. This tumour can often go undiagnosed for long periods.
Uncontrollable hypertension Headaches Malaise, muscle weakness, paresthesias, cramps, polyuria, and polydipsia. Sometimes low potassium level in the blood Prolong untreated disease may result in significant heart problems from long standing elevated blood pressure (left ventricular hypertrophy), which leads to myocardial infarction (heart attack) and stroke. Metabolic dysfunction (problems with metabolism), that can results in insulin resistance (diabetes) and gaining weight.
The cardinal anomaly causing primary aldosteronism syndrome is autonomous (nonsuppressible) aldosterone production. In addition to nonsuppressible aldosterone production, suppressed and poorly stimulative levels of plasma renin are coexisting with only mildly expanded intravascular and extravascular fluid volume. Normal regulation of aldosterone secretion is mediated to varying degrees by renin, serum potassium and sodium levels, intravascular volume status, and corticotropin.