Enlarged spleen is not normal and occurs as a consequence of another underlying disease. An enlarged spleen is caused by infections (mononucleosis,toxoplasmosis, endocarditis); liver diseases (cirrhosis); cancer; inflammatory diseases (rheumatoid arthritis,sarcoidosis); trauma; and infiltrated diseases (Gaucher disease, amyloidosis).
Signs of an enlarged spleen Weakness Easy bruising and shortness of breath (anemia) Weight loss (cancer) Fever (infection) Jaundice Nausea and vomiting (liver disease)
Symptoms of an enlarged spleen are usually due to the underlying disease or condition causing it; however, those individuals who do have symptoms may experience indigestion and a feeling of fullness because the enlarged spleen can compress the stomach, hiccups because of diaphragm irritation pain in the upper abdomen that may radiate to the back or shoulder blade. Statistics: Tropical splenomegaly syndrome (or hyperactive malarial syndrome) has a female-to-male incidence ratio of 2:1.