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It is a degenerative neurological disorder.Multiple system atrophy effects the nerve cells in specific areas of the brain and it causes problems with movement, balance, and autonomic functions of the body such as bladder control or blood-pressure regulation.MSA is also known as Shy-Drager syndrome. The symptoms of shy-drager are like Parkinson's disease-like symptoms.Currently there is no specific treatment available to cure multiple system atrophy.Physiotherapy can help to manage symptoms.
MSA is a progressive neurodegenerative disorder with an estimated annual worldwide incidence of about 0·6/100,000, rising to 3/100,000 in those aged over 50 years. Some say that there is no gender difference. However, others report a higher diagnosis rate in males, with a ratio of male:female of between 1:3 and 1:93. Most patients with MSA develop the disease when older than 40 years and the mean age at onset is between 50 and 70 years.