Polycythemia Vera

Share this page

Expert PPTs

Dimitris P Makris
Bio-chemistry
PPT Version | PDF Version
Elisa Moncarz
Transportation Services, hospitality industry
PPT Version | PDF Version

Speaker PPTs

Emanuele Corongiu
Role of percutaneous tibial nerve stimulation in the treatment of neurogenic overactive bladder syndrome.
PPT Version | PDF Version
Yosef Yarden
Classically, the 3âuntranslated region (3âUTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3âUTR alone, without all other elements in mRNA such as 5âUTR and coding region. The importance of independent 3âUTR RNA (referred as I3âUTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3âUTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3âUTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3âUTR were important for its tumor suppression activity. Then, the C/EBP 3âUTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3âUTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3âUTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990âs to 2000âs, world scientists found several 3âUTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3âUTR regions, although the existence of their transcribed products as independent 3âUTR RNAs is still to be confirmed. Our studies indicate that the independent 3âUTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
PPT Version | PDF Version
Anna Chrobok
Recoverable and recyclable catalysts for sustainable chemical processes
PPT Version | PDF Version
Amila Orucevic
Prognostic value of ER, PR, and HER2 breast cancer biomarkers and AJCCâs TNM staging system on overall survival of Caucasian females with breast cancer: An institutionâs 10 year experience
PPT Version | PDF Version
S Karthikeyan
Resveratrol modulates expression of ABC transporters in non-small lung cancer cells: Molecular docking and gene expression studies
PPT Version | PDF Version
Nihat Akin
Probiotic beverage from black carrot juice fermented with Lactobacillus casei
PPT Version | PDF Version
Tony Ifeanyi Ojiezeh
Haemogram and serum enzymes activities of Newcastle Disease Virus challenged broiler chickens following supplemental treatment with Aloe vera extract.
PPT Version | PDF Version
Charbell M.H. Kury
Real-life challenges in implementing public strategies for HPV vaccination in developing countries, and strategies to increase immunization coverage
PPT Version | PDF Version