Typhus refers to a group of infectious diseases that are caused by rickettsial organisms and that result in an acute febrile illness. Arthropod vectors transmit the etiologic agents to humans. The principle diseases of this group are epidemic or louse-borne typhus.After B quintana is introduced into the human body, it invades erythrocytes and endothelial cells, where it is protected from the host’s humoral immune response.Intraerythrocytic B quintana colonization is largely limited to human beings, while the invasion of vascular endothelial cells is less species-specific.
In the Canada, about 2,472 cases of Typhus fever are reported in each year. Almost 13% of the Canada population is suffering with Typhus fever, a disease caused by bacteria called Rickettsia typhi or bacteria called Rickettsia felis.When the disease is suspected, treat with moderate- to high-dose oral doxycycline or tetracycline. Scrub typhus is also treated with doxycycline, although chloramphenicol is used in more severe cases. Resistance is becoming widespread in Thailand in particular, where azithromycin remains effective. Azithromycin is also safe in pregnant women and children. With treatment, fatality of scrub typhus falls to less than 2%.