alexa Carboxyfullerenes: Nanomolecules that Work! | OMICS International
ISSN: 2155-983X
Journal of Nanomedicine & Biotherapeutic Discovery

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Carboxyfullerenes: Nanomolecules that Work!

Sameh S. Ali*

Department of Medicine, University of California, San Diego, USA

Center for Aging and Associated Diseases, Helmy Institute for Medical Sciences, Zewail City of Science and Technology, Sheikh Zayed District, Giza 12588, Egypt

*Corresponding Author:
Sameh S. Ali
Assistant Professor
Departments of Medicine and Anesthesiology
The University of California, USA
Tel: 858 5347956
Fax: 858 534 0104
E-mail: [email protected]

Received date: March 30, 2012; Accepted date: March 30, 2012; Published date: April 01, 2012

Citation: Ali SS (2012) Carboxyfullerenes: Nanomolecules that Work! J Nanomedic Biotherapeu Discover 2:e110. doi:10.4172/2155-983X.1000e110

Copyright: © 2012 Ali SS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Nanomedicine & Biotherapeutic Discovery

Buckminsterfullerene (C60) is a fascinating spherical molecule that is composed of pure carbon atoms bonded in fused aromatic rings [1]. The discovery of fullerenes essentially expanded the number of known carbon allotropes, which were limited to graphite, diamond and amorphous carbon. Due to their unique physicochemical properties, fullerenes (Buckyballs) and carbon nanotubes (buckytubes) have been the subject of intense research yielding numerous reported applications in material science, electronics, nanotechnology and more recently, biomedicine.

Why are fullerenes unique candidates for nanotherapeutic applications?

The diameter of the C60 molecule is 6.973 Å in a Chem3D®- generated molecular model (Figure 1A), but derivatization can qualify the molecule as a nanoparticle! In contrast to classical planar aromatic molecules, the curvature of the spherical carbon network gives fullerenes their unique chemical reactivity profile. That is, restrained geometry imparts somewhat incomplete lateral overlaps between the bond forming p-orbitals on the outer surface while enhancing their overlap internally (Figure 1A) [2]. The result is a highly reactive surface and a completely inert interior of the C60 molecule, allowing derivatization and transformation through redox and many other reactions.


Figure 1: Chem3D generated models for Buckminsterfullerene (C60) indicating the HOMO (Highest Occupied Molecular Orbital, N=120, E=-11.135 eV) as calculated by the Extended Hückel Semi Empirical Method (A) and the trismalonic acid C3 derivative (B).

Early on, fullerenes were recognized as ‘electron-sinks’ or ‘free radical sponges [3], with one molecule being capable of scavenging > 30 free radicals. However, the biomedical applications of fullerenes didn’t come to fruition before water-soluble full erenol derivatives were utilized as neuroprotectants in a groundbreaking study by Dugan, Choi and their co-workers [4]. Today, the biomedical application of watersoluble fullerenes has expanded dramatically to span areas of antiviral activity, antioxidant activity and drug delivery—among many other exciting new applications; reviewed in [5,6]. For example, designed fullerene derivatives that exhibit the size and symmetry to fit inside the hydrophobic cavity of the human immunodeficiency virus (HIV) effectively inhibit the catalytic activity of the HIV proteases; reviewed in [5,6]. Moreover, fullerenes can be utilized as radical scavengers and antioxidants, despite paradoxically producing singlet oxygen and free radicals when exposed to light; reviewed in [7]. Direct electron transfers between photoexcited fullerenes and DNA bases, along with generated oxygen radicals were employed to cleave DNA [8]. Additionally, functionalized fullerenes have been used as carriers for gene and drug delivery [9].

Carboxyfullerenes: The spearhead of nanomedicinal research!

One of the most promising classes of water-soluble fullerenes is carboxyfullerenes, especially the tris-malonic acid C3 derivative (Figure 1B). The high symmetry and partitioned lipophilic/hydrophilic characteristics of each molecule appear to enhance its ability to access various domains in the cell, to pass the blood-brain barrier and even to penetrate mitochondria thus acting as an antioxidant at the primary source of reactive oxygen species [10-12]. Interestingly, C3 has been shown to remove superoxide radicals catalytically rather than stoicheometrically thus acting as a superoxide dismutase mimetic [10]. The extraordinary neuroprotective efficacy of this molecule has been established in several models including iron-induced oxidative injury [13], NMDA-receptor mediated neurotoxicity [12], familial amyotrophic lateral sclerosis [14] and ketamine-induced loss of interneurons implicated in schizophrenic patients [15]. Strikingly, administration of C3 to wild-type mice starting at middle age improved their cognitive function and extended their lifespans [16]. These results provide great guidance for the development of effective fullerene-based drugs to intervene with the plethora of nervous system maladiesparticularly, those involving oxidative injury.

Proceed with caution!

On the cautionary side, extensive toxicological studies are essential before fullerene-based drugs or cosmetics are made available commercially. Although several in vitro studies concluded a little evidence of fullerene toxicity [17], it is important to stress the fact that fullerenes are pro-oxidants when activated by light. This is particularly relevant to skin care and anti-aging products that utilize fullerene formulations. Notably, polar and non-polar fullerenes tend to aggregate in aqueous media and the variability in aggregate size, shape and surface area within the same patch makes it a challenging task to define nanotoxicological standards. It is imperative that clear safety regulations are established to control every fullerene formulation before it is dispatched to the market. However, incomplete nanotoxicology research is hampering efforts to introduce such regulations [18]. This highlights the importance of the Journal of Nanomedicine & Biotherapeutics, as an open access source of data that can effectively aid decision makers to constitute nanotoxicology regulations.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 12125
  • [From(publication date):
    April-2012 - May 27, 2018]
  • Breakdown by view type
  • HTML page views : 8323
  • PDF downloads : 3802

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7