alexa Scholarly Journals In Suicide Gene Therapy|OMICS International|Journal Of Cell Science And Therapy

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Scholarly Journals In Suicide Gene Therapy

Scholarly journal is a peer-reviewed journal in which scholarship relating to a particular academic discipline is published. Scholarly journals serve as forums for the introduction and presentation for scrutiny of new research, and the critique of existing research. Content typically takes the form of articles presenting original research, review articles, and book reviews. The term Scholarly journal applies to scholarly publications in all fields; this article discusses the aspects common to all academic field journals. Cancer and its treatment are an immense burden not only on the individual patient but also on the entire healthcare system. A major limitation of conventional chemotherapies used in cancer treatments today are low therapeutic indices and side effects that result from drug effects on normal tissues (off target). One of the most innovative approaches to developing antineoplastic agents with increased tumor selectivity is the use of suicide gene therapy. Suicide gene therapy involves delivering a gene product in proximity to the targeted cancer tissue through various targeted delivery methods followed by tissue/tumor-specific expression of the gene product which then converts a systemically available pro-drug into an active drug within the tumor locale. In suicide gene therapy, gap junctions allow local diffusion of the active drug resulting in an enhanced effect. In addition, a bystander effect can be mediated through the enhanced immune response as an effect of the resulting cancer necrosis which can sensitize the immune system independently from the expressed suicide gene. Suicide gene therapy is based on the introduction of genes into tumor tissue which ultimately results in cancer cell death. (Rajab K, Nelson P, Keung EZ, Conrad C, Suicide Gene Therapy against Cancer)
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Last date updated on July, 2014

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