Diffuse idiopathic skeletal hyperostosis
Pathophysiology: Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier's disease, affects the ligaments around the spine. Sections of the ligaments turn into bone in this disorder, which is considered to be a form of degenerative arthritis.
Symptoms: • Diffuse Idiopathic Skeletal Hyperostosis • DISH • Forestier's Disease • Spinal Diffuse Idiopathic Skeletal Hyperostosis • Spinal DISH • Vertebral Ankylosing Hyperostosis
Treatment: Anti-inflammatory drugs, including non-steroid anti-inflammatory drugs (NSAIDS) are often prescribed. In relatively rare cases, surgery to correct deformities may be prescribed. Other treatment is symptomatic and supportive.
Major Research: Researchers at the university's Bone and Joint Initiative collaborated with Doo-Sup Choi at the Mayo Clinic in Rochester, Minn., to come up with the first mouse model of this disease. This model will allow us for the first time to uncover the mechanisms underlying DISH and related disorders.