Pathophysiology: Dupuytren's contracture is a thickening of the fibrous tissue layer underneath the skin of the palm and fingers. Although painless, the thickening and tightening (contracture) of this fibrous tissue can cause the fingers to curl (flex).
Symptoms: Tender lumps (nodules) form in the palm, tough bands of tissue under the skin and Curled fingers.
Treatment: Two most common surgical techniques are: • open fasciotomy – where the shortened connective tissue is cut to relieve tension • fasciectomy –where the shortened connective tissue is removed .
Major Research: NICE has confirmed its previous final draft guidance not to recommend collagenase clostridium histolyticum (Xiapex, Swedish Orphan Biovitrum AB), a treatment for Dupuytren’s contracture for routine use. Instead further re