Neuroblastoma is a disease in which malignant (cancer) cells form in nerve tissue of the adrenal gland, neck, chest, or spinal cord. Neuroblastoma often begins in the nerve tissue of the adrenal glands. There are two adrenal glands, one on top of each kidney in the back of the upper abdomen. The adrenal glands make important hormones that help control heart rate, blood pressure, blood sugar, and the way the body reacts to stress. Neuroblastoma may also begin in the abdomen, in the chest, in nerve tissue near the spine in the neck, or in the spinal cord. Neuroblastoma most often begins during early childhood, usually in children younger than 5 years of age.
After correction for multiple comparisons, only rs204926 in LMO1 remained significantly different between cases and controls (OR = 0.45, 95% CI: 0.31–0.65, adjusted P = 0.003). In addition, 16 haplotypes in four separate genes were significantly different between case and control groups at an unadjusted P value < 0.05, 11 of which were located in LMO1. Despite the development of new treatment options, the prognosis of high?risk neuroblastoma patients still remains poor; in more than half of patients the disease returns. Stem cell rescue replaces blood?forming stem cells that were destroyed by high?dose chemotherapy in order to recover the bone marrow. It is also known as myeloablative therapy and might improve the survival of these patients.