Sclerosing mesenteritis is an uncommon idiopathic disorder characterised by chronic non-specific inflammation involving the adipose tissue of the bowel mesentery.Sclerosing mesenteritis occurs when the tissue mesentery that holds the small intestines in place becomes inflamed and forms scar tissue.Sclerosing mesenteritis can cause abdominal pain, bloating and diarrhea. In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through your digestive tract. Surgery may be necessary in this situation.
There is considerable overlap between these inflammatory conditions often leading to diagnostic and therapeutic confusion. sclerosing mesenteritis is asymptomatic, gastrointestinal symptoms such as abdominal pain, nausea/vomiting, bloating, loss of appetite, weight loss and diarrhea or constipation, Occasionally, intermittent partial bowel obstruction is encountered. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.
Includes abdominal surgery or trauma , autoimmunity , paraneoplastic syndrome, ischaemic injury and infection.small bowel mesentery is affected in most cases although the sigmoid mesocolon and omentum can also be occasionally be involved. The disease includes three stages. Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat. Stage-2: mesenteric panniculitis, inflammatory reaction. Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.