Pathophysiology: Hepatitis refers to an inflammatory disease which is fairly common and mainly affects the liver. Viral hepatitis is classified as A, B, C, D, E and G. All types of hepatitis viruses cause similar kind of liver damage. Inflammation happens throughout whole liver and hepatocytes are destroyed by cytotoxic cytokines and natural killer cells being part of inflammatory process. Cellular necrosis takes place but liver usually able to repair itself and regain complete function if no other complications occur.
Disease Statistics: In China, early childhood show more rate of chronic hepatitis B virus (HBV) infection. Hepatitis B is more prevalent in the southern part and C more prevalent in the northern part of China. Introduction of HBV vaccination in infants saw prevalence declining from 9.75% in 1992 to 7.18% in 2006. The prevalence of HEV is high in China.
Treatment: Intravenous rehydration is given as supportive care but no specific emergency treatment is recommended as such. Patients are admitted in conditions of severe complications. Evaluation for hepatic encephalopathy is done. Certain patients may benefit from pharmacologic therapy. Patients are advised to avoid prolonged or vigorous physical exertion until their symptoms improve and maintain adequate hydration.
Research: Recent studies have been more towards HEV with major projects are done under the authority of China Centres for Disease Control and Prevention, China Ministry of Health and Ministry of Science and Technology.