|Chromosome abnormality journals describes briefly about multiple myeloma also known as plasma cell myeloma or Kahler's disease (after Otto Kahler), is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. In multiple myeloma, collections of abnormal plasma cells accumulate in the bone marrow, where they interfere with the production of normal blood cells. Most cases of myeloma also feature the production of a paraproteinâan abnormal antibody which can cause kidney problems. Bone lesions and hypercalcemia (high calcium levels) are also often encountered.Myeloma is diagnosed with blood tests (serum protein electrophoresis, serum free kappa/lambda light chain assay), bone marrow examination, urine protein electrophoresis, and X-rays of commonly involved bones.
Chromosome abnormality journals in which myeloma is generally thought to be incurable but highly treatable. Remissions may be induced with steroids, chemotherapy, proteasome inhibitors, immunomodulatory drugs (IMiDs) such as thalidomide or lenalidomide, and stem cell transplants. Radiation therapy is sometimes used to reduce pain from bone lesions. Myeloma develops in 1â4 per 100,000 people per year. It is more common in men and for unknown reasons is twice as common in African-Americans as it is in European-Americans. With conventional treatment, median survival is 3â4 years, which may be extended to 5â7 years or longer with advanced treatments. Multiple myeloma is the second most common hematological malignancy in the U.S. (after non-Hodgkin lymphoma), and constitutes 1% of all cancers. . Multiple myeloma journals include disorders related to plasma cells of the human body.