Open Access journals are the major source of knowledge for young and aspiring generations who are keen in pursuing a career in sciences. This system provides easy access to networks of scientific journals. Authors that contribute their scholarly works to Open Access journals gain remarkable reputation as the research scholarly explore these works extensively. Because of the free access open access journals impact factors are improving.
The eukaryotic chromosome is linear, with a centromere and telomere. The chromosome replicates from the origin of replication during the S-phase of the cell cycle. The centromere proteins, CENP-A,-B, and -C, located in the centromere sequence, assist with assembly of the kinetochore complex during the M phase. Then, the spindle fiber is attached to the kinetochore, and the chromosome is distributed to both poles. In this way, replicating chromosomes are distributed to daughter cells, and the genomic information of a mother cell is stably transmitted to daughter cells. Physiologically, the same mechanisms are used for the replication and distribution of HAC vectors. "Mitsuo Oshimura, Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells"
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Last date updated on June, 2014