alexa Obesity|OMICS International|Clinical Trials

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Obesity

Obesity is a major health problem in the United States and worldwide. Alterations in drug metabolism in obese individuals were reported in the early eighties. Drug metabolism is primarily regulated by the Drug Metabolizing Enzymes (DMEs), which are broadly classified into phases I and II. Phase I DMEs primarily comprise of the Cytochrome (CYP) 450 family of enzymes. CYP3A4 is the most common isoform expressed in human liver and metabolizes ~50% of known drugs. Phase II metabolism consists of conjugation reactions such as glucuronidation, sulfation, glutathione conjugation or methylation forming polar metabolites leading to enhanced excretion
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Last date updated on July, 2014

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