Prostate Cancer

In prostate cancer epithelial tissues, genetic progression and loss of cellular control functions are observed as the cell and tissue phenotype changes from normal to dysplasia (prostatic intraepithelial neoplasia or PIN), then to increasingly severe dysplasia (high grade PIN or HGPIN), to superficial cancers and finally to invasive disease. lthough it is clear that clinical CaP incidence and mortality vary greatly between populations, the frequency of latent CaP is evenly distributed among populations, suggesting that external factors such as diet, physical activity and other lifestyle factors are important in the transformation from latent into more aggressive, clinical cancer. The features of prostate cancer, namely high prevalence, long latency, significant mortality and morbidity, and the availability of HGPIN and ASAP as intermediate predictive stages of progression, provide the most promise for evaluating agents for chemoprevention

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Last date updated on April, 2024