alexa Clinical Value and Indications of 131I Treatment after Surgery for Differentiated Thyroid Cancer | OMICS International
ISSN: 2155-9619
Journal of Nuclear Medicine & Radiation Therapy

Like us on:

Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields.
Meet Inspiring Speakers and Experts at our 3000+ Global Conferenceseries Events with over 600+ Conferences, 1200+ Symposiums and 1200+ Workshops on
Medical, Pharma, Engineering, Science, Technology and Business

Clinical Value and Indications of 131I Treatment after Surgery for Differentiated Thyroid Cancer

Quan-Yong Luo*

Department of Nuclear Medicine, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, 600 Yishan Rd., Shanghai 200233, China

*Corresponding Author:
Quan-Yong Luo
Department of Nuclear Medicine
Shanghai Sixth People’s Hospital
Shanghai Jiao Tong University
600 Yishan Rd, Shanghai 200233, China
E-mail: [email protected]

Received date: September 07, 2012; Accepted date: September 10, 2012; Published date: September 17, 2012

Citation: Luo QY (2012) Clinical Value and Indications of 131I Treatment after Surgery for Differentiated Thyroid Cancer. J Nucl Med Radiat Ther 3:e104. doi:10.4172/2155-9619.1000e104

Copyright: © 2012 Luo QY. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Visit for more related articles at Journal of Nuclear Medicine & Radiation Therapy

According to statistics, thyroid cancer is the malignant tumor with the fastest growing morbidity over the past 20 years, especially in females and young people [1,2]. Differentiated thyroid cancer (DTC) accounts for most cases of thyroid cancer, and is divided mainly into papillary and follicular thyroid carcinomas. Its prognosis is good, but recurrence and metastasis can occur in some patients [3].

The combination of surgery, iodine131 (131I) therapy, and thyroid hormone treatment is an effective and acceptable therapeutic scheme for most DTC patients [4]. The first step in DTC treatment involves resection of the tumor and the affected thyroid tissue. Total resection or subtotal resection of the thyroid is preferred, to better prepare for postoperative 131I treatment, to improve the curative effect, and to reduce recurrence. However, total resection is rarely adopted, because of the risk of complications, and postoperative 131I treatment is therefore necessary. 131I treatment has two major purposes: ablating the residual thyroid cancer cells and treating DTC metastases.

There are several clinical reasons for using 131I treatment to ablate residual tumor tissues after DTC surgery. (1) 131I treatment can completely ablate very small tumor foci that may be hidden in the residual thyroid tissue after surgery, thus reducing local relapse. (2) After complete removal of the residual thyroid gland, serum thyroglobulin (Tg) becomes a sensitive tumor marker for monitoring recurrence and metastases after DTC surgery. 131I treatment thus improves the sensitivity of Tg as an indicator of recurrence and metastases, making it useful for long-term follow-up. (3) Ablation of residual thyroid tissue eliminates its competition for 131I intake, thus increasing 131I uptake by metastases and improving the sensitivity of 131I whole-body scanning for the detection of metastases.

Metastasis of papillary thyroid carcinoma mainly involves the lymph nodes, while metastases of follicular thyroid carcinoma involve the lungs and bone. 131I treatment of lymph node metastasis is mainly targeted at metastatic lymph nodes smaller than 1 cm, with good 131I intake, and favorable therapeutic effects can be achieved after repeated 131I treatment. Repeated 131I treatment of lung metastasis from DTC results in the reduction or disappearance of foci in most patients, and partial or complete alleviation of symptoms. The main effect of 131I treatment of bone metastasis is in alleviating pain; it can relieve or eliminate bone pain in most patients. At the same time, 131I treatment can also enable biochemical relief, reducing serum levels of the tumor marker Tg [5]. Apart from using 131I to treat metastases, 131I wholebody scanning can also be used to detect and qualitatively analyze new metastases. 131I thus has dual functions of diagnosis and treatment in relation to DTC metastases.

The decision to administer 131I treatment after DTC surgery should depend on the risks of relapse and death. I support the ESMO Clinical Practice Guidelines and European Consensus that classifies the risk of DTC as high, low, or extremely low. High-risk patients are those with tumors > 4 cm, with extraglandular invasions, lymph node and distant metastases, or with incompletely resected tumors. Low-risk patients refer to those whose thyroid glands were incompletely resected and who did not receive lymph node dissection, those with a tumor diameter of 1-4 cm, adolescent patients, or those with invasive pathological manifestations. Extremely-low-risk patients are those with a single focus without extraglandular invasions, with no lymph node, or distant metastases, no invasive pathological manifestations, a tumor diameter < 1 cm, or whose thyroid gland was completely resected [6,7].

It is generally believed that high-risk DTC patients should receive postoperative 131I treatment, while extremely-low-risk patients do not require 131I treatment. However, the need for postoperative 131I treatment in low-risk patients is controversial. Indeed, the highly influential ‘New England Journal of Medicine’ recently published two randomized, multicenter clinical studies of postoperative 131I treatment in low-risk DTC [8,9]; a comparison and assessment of the therapeutic effects of low- and high-dose 131I (30 mCi and 100 mCi, respectively). With respect to the ablation of residual tissue and reductions in serum Tg, low-dose 131I treatment was comparable to high-dose 131I treatment. The incidence of adverse events, however, was significantly lower in patients treated with low-dose 131I, providing convincing evidencebased support for the use of 131I treatment in low-risk DTC patients. However, it is important to balance the advantages and disadvantages of 131I treatment in low-risk DTC patients. Low-dose 131I treatment is associated with a lower incidence of adverse events, with no change in therapeutic effect, and is therefore recommended in low-risk DTC patients. The prognosis of low-risk DTC is good and patients can survive for prolonged periods, highlighting the importance of longterm follow-up visits. The value of the tumor marker Tg is increased after 131I treatment, and can thus be used for long-term and life-long follow-up of low-risk patients. I therefore recommend that all DTC patients, except those classified as extremely low-risk, should receive 131I treatment after thyroid gland resection.


Select your language of interest to view the total content in your interested language
Post your comment

Share This Article

Recommended Conferences

Article Usage

  • Total views: 11814
  • [From(publication date):
    August-2012 - Jul 19, 2018]
  • Breakdown by view type
  • HTML page views : 8024
  • PDF downloads : 3790

Post your comment

captcha   Reload  Can't read the image? click here to refresh

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7