Alicia L. Bertone
The Trueman Chair in Equine Clinical Medicine and Surgery
The Ohio State University
The CORL’s research has focused on the translational science in the area of gene therapy, cell therapy, and molecular engineering. The laboratory has demonstrated that the direct and cell-based gene therapy can promote improved healing of bone and cartilage tissue with rodent and equine models by using sophisticated imaging and gene expression analysis. These gene therapy strategies have already entered a clinical trial for complicated orthopedic disorders in various veterinary patients such as dogs, horses, and llamas. In addition, the laboratory has extensive studied the RNA-silencing technology to modurate cytokine activities for the treatment of arthritis with rodent models. Moreover, CORL has performed a number of equine exercise physiology projects to study the pharmacokinetics of several medications used for the treatments of musculoskeletal diseases. Furthermore, the laboratory has investigated the efficacy and safety of platelet-rich plasma therapy for the treatments of joint and ligament disorders as it’s already moved forward to clinical trials of equine patients with osteoarthrits and ligament injuries. All of these research works have shown extensive promising results, and some of therapeutic methods have already been applied for clinical cases with orthopedic conditions to make substantial contributions on health and welfare of veterinary patients and clients.
Dr Bertone has an interest in the molecular and stem cell therapy for various orthopedic disorders, pharmacokinetics of medications for the treatments of musculoskeletal diseases, nuclear imaging to study equine arthritis, and autologous blood products for equine bone and joint disorders. Dr Bertone has also designed the first commercial-grade equine microarray (equine GeneChip®). Dr Bertone is the Director of the Comparative Orthopedic Research Laboratories (CORL) in the College of Veterinary Medicine at The Ohio State University (OSU). Dr Bertone serves in the Trueman Endowed Chair at OSU, as well as the Director of Basic Science and Industry Contracts in Sports, Health and Performance Institute at OSU.