The Mount Sinai Hospital
Carlos Cordon-Cardo, MD, Ph.D., a distinguished physician-scientist and recognized internationally for his groundbreaking research in experimental pathology and molecular oncology, holds the appointment of Chair for the Department of Pathology at The Mount Sinai Medical Center. Cordon-Cardo is a leader in the mechanisms of tumor suppression. His research has focused on the analyses of multidrug resistance and alteration of tumor suppression genes in human cancer. He developed and implemented an oncologic molecular pathology discipline and helped create the \\\"systems pathology\\\" platform. This approach uses systems biology to form mathematical models of the interaction and behavior of cancer cells with the goal of determining tumor pathogenesis and clinical outcome. Cordon-Cardo\\\'s contributions to cancer research have had important implications for tumor suppression, particularly in bladder and prostate cancers, and soft tissue sarcomas. Currently, his research is aimed at understanding the cooperative effects of mutations of cell-cycle regulation, and genes that prevent cell death cancer. Additionally, he is developing and characterizing animal models for loss of function of specific pathways by targeted gene disruption using bladder cancer and sarcomas. Recent studies from his laboratory have linked adult stem cells and cancer, revealing that certain tumors originate from distinct differentiation stages in stem-cell fate and development. A frequently cited author, Cordon-Cardo has received National Cancer Institute funding for his research. He has developed numerous patents, is a dedicated mentor, and he holds prominent posts in several national and international professional organizations. Dr. Cordon-Cardo has outlined a broad vision that redefines the discipline of Pathology, placing it at the core of patient management and individualized medicine. He is aggressively recruiting senior and junior faculty, identifying and developing subspecialty areas, such as molecular and systems pathology programs, and expanding biorepositories and databases to further enhance translational research, converting his vision into a reality. Prior to joining Mount Sinai, Cordon-Cardo served as Vice-Chair of Pathology, Professor of Pathology, and Urology, and Associate Director for Infrastructure at the Herbert Irving Comprehensive Cancer Center at Columbia University College of Physicians and Surgeons. He also created the Division of Molecular Pathology at Memorial Sloan-Kettering Cancer Center and served as its first director. Dr. Cordon-Cardo obtained his MD from the Autonomous University of Barcelona, Spain, in 1980, and his PhD in Cell Biology and Genetics from Cornell University Medical College in 1985.
Experimental pathology and molecular oncology