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Helen Philippou

Helen Philippou

University of Leeds

Associate Professor

Biography

Dr Philippou completed her Ph.D in 1997, from the University of London (Charing Cross and Westminster Medical School), UK and immediately obtained a tenured post at Imperial College (London), UK followed by the University of Leeds, UK, where she is an Associate Professor. She is Academic Theme Lead of Translational Cardiovascular Research, at the University of Leeds. She is also the current Chairman of the FXIII and Fibrinogen Subcommittee of the International Society of Thrombosis and Haemostasis.

Research

My research since 1992 has focused on understanding mechanisms of thrombosis, in particular to the coagulation pathway. Currently my group is looking into the discovery of novel therapeutics against thrombosis that will be taken orally and will have safer bleeding profiles than other antithrombotics currently available or in development. I am also interested in understanding novel mechanisms that regulate the activity of coagulation factors. In addition, we are investigating hyperhomocysteinemia with respect to understanding its role in clot formation and its stability. Overall, we have established many methodologies that enable us to investigate clot formation and its stability in vitro and in vivo. These methodologies are being used to understand the nature of protein-protein interactions and other mechanisms involved in the coagulation pathway with respect to blood clot formation and its ability to be lysed by the fibrinolyitc pathway.