John S.D. Chan
Professor of Medicine and Physiology
Universite de Montreal, Canada
John S.D. Chan has completed his Ph.D, at the University of Manitoba (Canada) and research training in Canada and the USA including National Institutes of Health (NIH) and Harvard Medical School (Boston). He is the Professor of Medicine at the Université de Montréal and the Director of the Laboratory of Molecular Nephrology and Endocrinology at the Research Centre of Centre hospitalier de l’Université de Montréal (CRCHUM)-Hotel Dieu Hospital. He has published more than 110 papers in reputed journals and is the Editor of the eBook, “Diabetic Nephropathy”.
The role of intrarenal RAS and ROS in the pathogenesis of diabetic nephropathy, with special emphasis on renal angiotensinogen gene expression and intrarenal ROS generation on tubular apoptosis in diabetes. Transgenic mice specifically overexpressing angiotensinogen and catalase in the kidney will be used to study the molecular mechanism(s) of intrarenal RAS and ROS action on the induction of tubular fibrosis and apoptosis in diabetes. Gene chip microarrays will be used to identify the unique genes that are differentially expressed in diabetic kidneys. The physiological role(s) of these unique genes will be studied in vitro and in vivo.