Marjan De Mey
Ghent University, Belgium
Dr Marjan De Mey is an Associate Professor in Metabolic Engineering of Microorganisms and her centre of expertise is in industrial biotechnology and biocatalysis. She was a Visiting Scientist at laboratory of metabolic engineering and bioinformatics at Massachusetts Institute of Technology, Cambridge, US
Metabolic Engineering, Synthetic Biology and System Biology Targeted and combinatorial genetic engineering, fermentation technology, analytical techniques and mathematical modeling are used to redesign microorganisms to better understand their operation and to make good use of them for production of bio-based materials from renewable resources. Balancing pathways, Fine-tuning of gene expression The introduction of new genes from e.g. plants into microorganisms enhances their capabilities, but also requires special understanding of measures to be taken to preserve the viability of these microorganisms. Especially in the case of multi-gene, branched and/or poorly understood pathways, transferring such pathways into a heterologous production host often leads to flux imbalances as they typically lack the complex regulatory mechanisms that are vital for efficient operation of these complex pathways.