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Mohamed E.H. ElSayed

Mohamed E.H. ElSayed

Department of Biomedical Engineering &
Macromolecular Science and Engineering
Program
University of Michigan

Biography

Dr. ElSayed received his BS of Pharmacy & Pharmaceutical Chemistry from Cairo University in May 1994. In July 2002, he obtained Ph.D. in Pharmaceutical Sciences from the University of Maryland where he investigated the effect of the physicochemical properties of dendritic carriers on their transport across epithelial and endothelial barriers under the supervision of Professor Hamidreza Ghandehari. Soon after his graduation, Dr. ElSayed joined the University of Washington, Department of Bioengineering to work with Professors Allan Hoffman and Patrick Stayton on the development of pH-sensitive polymeric carriers for delivery of therapeutic nucleic acids into epithelial cancer cells for treatment of breast cancer. In January 2007, Dr. ElSayed joined the Department of Biomedical Engineering at the University of Michigan where he has established the Cellular Engineering and Nano-Therapeutics Laboratory (www.bme.umich.edu/centlab.php). His research program utilizes a multidisciplinary approach to develop bio-inspired drug delivery systems that enhance the therapeutic activity of the incorporated drug molecules while eliminating or minimizing their potential side effects with particular emphasis on rational design and synthesis of novel biomaterials for drug and gene delivery, bio-nanotechnology, and “smart” therapeutics. Dr. ElSayed received several honors and awards including the National Cancer Center Fellowship, Susan G. Komen Postdoctoral Fellowship, US Department of Defense Award, US National Science Foundation CAREER Award, and Coulter Foundation Translational Research Partnership in Biomedical Engineering Award.

Research

Dr. ElSayed's research program focuses on the development of bio-inspired drug delivery systems that enhance the therapeutic activity of the incorporated drug molecules while eliminating or minimizing their potential side effects. He follows two parallel approaches to achieve this goal. First, he aims to better understand the mechanism(s) of transport of small molecules, macromolecules, and polymeric drug delivery systems across epithelial and endothelial barriers under normal and pathological conditions. Second, he rationally designs and synthesizes novel small and macromolecular carriers that can effectively exploit established transport mechanisms to “communicate” with the different epithelial and endothelial barriers encountered within the body to selectively deliver their therapeutic cargo to the diseased tissues with cellular and sub-cellular accuracy. Specific areas of research include: * Rational design and synthesis of novel “smart” therapeutic and imaging particles. * Development of in vitro models of epithelial/endothelial barriers in microfluidic channels. * Molecular engineering of oral “biomimetic” drug delivery systems. * Applications of therapeutic ultrasound in drug delivery to solid tumors.