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Patrick M Woster

Patrick M Woster

Medical University of South Carolina

Professor/Smart State Endowed Chair/Director


Patrick M. Woster received a B.S. in Pharmacy from the University of Nebraska Medical Center in 1978, and a Ph.D. in Medicinal Chemistry from the University of Nebraska - Lincoln in 1986. Following postdoctoral work in chemistry at Rensselaer Polytechnic Institute (1986), and in medicinal chemistry at the University of Michigan (1987), he joined the Wayne State University Faculty of Pharmacy in 1988. In 2011, he was appointed as Professor and SmartState™ Endowed Chair in Drug Discovery at the Medical University of South Carolina. He also serves as Director of the MUSC Drug Design and Synthesis Core. Ongoing research projects in the Woster laboratories include the synthesis of alkylpolyamines as antitumor or antiparasitic agents, design and synthesis of mechanism-based enzyme inhibitors, synthesis of inhibitors of chromatin-remodeling enzymes such as histone deacetylases and histone demethylases, and studies aimed at elucidating the cellular mechanisms of epigenetic modulators.


Design, synthesis and biological evaluation of epigenetic modulators, antitumor and antiparasitic agents