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Yan-Hua Chen

Yan-Hua Chen

Associate Professor
Department of Anatomy and Cell Biology
East Carolina University, USA
Tel: 252-744-1341
Fax: 252-744-2850



Our laboratory is interested in the regulation of tight junction barrier function and the signaling pathway(s) involved in tight junction assembly and disassembly. Tight junctions serve as a permeability barrier in epithelial and endothelial cells regulating the passage of ions and small molecules through the paracellular pathway. Tight junction plays a crucial role in maintaining tissue homeostasis by keeping the extracellular fluid within the physiological range. Recent studies indicate that disruption of tight junction function leads to a number of human diseases such as autosomal recessive deafness and renal magnesium wasting resulting in nephrocalcinosis.