Department of Anatomy and Cell Biology
East Carolina University, USA
Our laboratory is interested in the regulation of tight junction barrier function and the signaling pathway(s) involved in tight junction assembly and disassembly. Tight junctions serve as a permeability barrier in epithelial and endothelial cells regulating the passage of ions and small molecules through the paracellular pathway. Tight junction plays a crucial role in maintaining tissue homeostasis by keeping the extracellular fluid within the physiological range. Recent studies indicate that disruption of tight junction function leads to a number of human diseases such as autosomal recessive deafness and renal magnesium wasting resulting in nephrocalcinosis.