Group Leader Department of Virology Pasteur Institute, Paris Tel: 331-456-887-53
Yves Jacob, MD, PhD is group leader in virus-host interactomics in the Molecular Genetics of RNA Viruses Unit in the Department of Virology, Pasteur Institute Paris. He has received a MD from Lariboisière-St Louis School of Medicine, Paris University in 1983 (mentor Prof Jean Dausset, awarded Nobel Prize 1980), and after a three years residency/clinicat in Necker Hospital in Paris, he joined the Pasteur Institute and received a PhD in Philosophy from the Denis Diderot University in 1992. Since 2001, after completing his postdoctoral training in virology, his is senior scientist in the Department of Virology at Pasteur Institute in Paris. The main line of investigation of his team concerns virus/host interactomics with pioneering analyses using high-throughput innovative approaches combining a yeast two-hybrid pipeline with an orthogonal assay performed in human based on complementation of a split-luciferase. Since several years, a close collaboration was also established with the Center for Cancer Systems Biology (CCSB, Harvard Medical School), a center of excellence which has generated first-draft models of the human interactome. By plugging virus interactomics datasets onto these models, the main goal of his team is to answer questions such as how perturbations in complex networks induced by viral hijacking lead to pathogeny. Since 2012, Dr Jacob shared time between Pasteur Institute in Paris and CCSB in Boston.